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Anemia
Colorectal cancer and anemia interact to increase angiogenesis and cancer proliferation markers
August 7th, 2006
Colorectal cancers and anemia interact to increase angiogenesis and cancer proliferation markers. "Anemia has been implicated in the decreased oxygen tension noted within the tumor environment. In a series of 79 colorectal adenocarcinomas we investigated the role of anemia in activating molecular pathways regulated by hypoxia," investigators in Greece report. "Preoperative Hb levels were correlated with the immunohistochemical expression of hypoxia-inducible factor (HIF)1 alpha and HIF2 alpha, lactate dehydrogenase 5 (LDH5), glucose transporter 1 (GLUT1), vascular endothelial growth factor (VEGF), DEC1 and Bcl-2/adenovirus E1B 19 kd-interacting...
Source: Gastroenterology Week (2006-08-07)
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