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Gastroenterology
Enzyme inhibitor may provide strategy to treat some gastrointestinal problems
August 7th, 2006
Drugs that block the activity of an enzyme might hold a key to treating chronic and severe disorders such as certain forms of constipation, hemorrhoids, anal fissures, Hirschsprung disease and other similar gastrointestinal problems. Researchers led by Satish Rattan, DVM, professor of medicine in the Division of Gastroenterology and Hepatology at Jefferson Medical College of Thomas Jefferson University in Philadelphia, have shown that the enzyme Rho kinase (ROK) plays an important role in maintaining the tone of the internal anal sphincter (IAS), which is crucial for normal bowel functioning. When the IAS tone is too high - or "hypertensive" - the result can be...
Source: Gastroenterology Week (2006-08-07)
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