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Antimicrobial Resistance
Helicobacter pylori lipid A phosphatase is required for polymyxin resistance
August 7th, 2006
The lipid A 1-phosphatase of Helicobacter pylori is required for resistance to the antimicrobial peptide polymyxin. According to scientists writing in the Journal of Bacteriology, "Modification of the phosphate groups of lipid A with amine-containing substituents, such as phosphoethanolamine, reduces the overall net negative charge of Gram-negative bacterial lipopolysaccharide, thereby lowering its affinity to cationic antimicrobial peptides. Modification of the 1 position of Helicobacter pylori lipid A is a two-step process involving the removal of the 1-phosphate group by a lipid A phosphatase, LpxEHP (Hp0021), followed by the addition...
Source: Gastroenterology Week (2006-08-07)
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