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Gastric Cancer

Gastric cancer risk was low in Caucasians carrying Allele 6 due to higher pepsinogen C expression

Published in Gastroenterology Week, November 6th, 2006

Caucasians carrying Allele 6 were protected from the development of gastric cancer probably due to higher expression of pepsinogen C (PGC).

According to a recent report, researchers in Portugal conducted research "to study the role of an insertion/deletion polymorphism in the PGC gene, an effective marker for terminal differentiation of the stomach mucosa, in the susceptibility to the development of gastric lesions."

"The study was performed with 99 samples of known gastric lesions and 127 samples without evidence of neoplastic disease. PCR was employed and the 6 polymorphic alleles were amplified: Allele 1 (510 bp), Allele 2 (480 bp), Allele 3/4...

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