Proteinuria Cell Biology
Researchers from University of Tokyo, Division of Nephrology detail new studies and findings in the area of proteinuria cell biology
Published in Gastroenterology Week, November 6th, 2006
Scientists discuss in "Albumin induces endoplasmic reticulum stress and apoptosis in renal proximal tubular cells" new findings in proteinuria. "Chronic proteinuria appears to be a key factor in tubulointerstitial damage. Recent studies have emphasized a pathogenic role of endoplasmic reticulum (ER) stress which is induced by the accumulation of misfolded proteins in ER, extracellular stress, etc," scientists in Tokyo, Japan report.
"In the present study, we investigated ER stress and ER stress-induced apoptosis in proximal tubular cells (PTCs). Immortalized rat PTCs (IRPTCs) were cultured with bovine serum albumin (BSA). The viability of IRPTCs decreased...
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