Cancer Gene Therapy

Researchers at Technical University of Munich target cancer gene therapy

Published in Gastroenterology Week, February 5th, 2007

Research findings, "Lack of RUNX3 regulation in human gastric cancer," are discussed in a new report. "It has been proposed that the transcription factor RUNX3 is the product of a gastric tumor suppressor gene. We examined RUNX3 expression in gastric biopsies from 105 patients with different histological presentations," scientists in Munich, Germany report.

"Surprisingly, immunohistochemical staining detected RUNX3 protein expression only in infiltrating leukocytes but not in the gastric epithelium. Using laser capture microdissection and quantitative reverse transcription-polymerase chain reaction, we confirmed that the level of RUNX3 mRNA expression in the gastric...

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Source: Gastroenterology Week (2007-02-05)

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