Cancer Gene Therapy
Scientists at Kumamoto University report research in cancer gene therapy
Published in Gastroenterology Week, March 19th, 2007
A new study, "Up-regulation of 150-kDa oxygen-regulated protein by celecoxib in human gastric carcinoma cells," is now available. "Induction of apoptosis by nonsteroidal anti-inflammatory drugs, such as celecoxib, is involved in their antitumor activity. An endoplasmic reticulum chaperone, 150-kDa oxygen-regulated protein (ORP150) is essential for the maintenance of cellular viability under hypoxia and is reported to be overexpressed in clinically isolated tumors," investigators in Kumamoto, Japan report.
"We here found that ORP150 was up-regulated by celecoxib in human gastric carcinoma cells. In conjunction with the suppression of tumor growth, orally administered...
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