Thrombosis Immunology

Data on thrombosis immunology described by researchers at Karolinska University, Department of Vascular Surgery

Published in Gastroenterology Week, September 17th, 2007

Fresh data on thrombosis are presented in the report "Presence of NGAL/MMP-9 complexes in human abdominal aortic aneurysms. It has been suggested that the intraluminal thrombus of abdominal aortic aneurysms (AAAs) predisposes for AAA enlargement and rupture. The growth of the AAA is dependent on proteolytic degradation of elastin," scientists in Sweden report.

"Here, we analysed whether the neutrophil gelatinase-associated lipocalin (NGAL) is expressed within the thrombus and the aneurysm wall. NGAL can bind to metalloproteinase-9 (MMP-9) and inhibit its degradation, thereby preserving enzymatic activity. Biopsies were obtained from thrombus-free and thrombus-covered...

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Source: Gastroenterology Week (2007-09-17)

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