Biochemistry

Research data from University of Louvain update understanding of biochemistry

Published in Gastroenterology Week, September 17th, 2007

According to recent research from Brussels, Belgium, "AICA riboside (5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside) has been extensively used in cells to activate the AMPK (AMP-activated protein kinase), a metabolic sensor involved in cell energy homoeostasis. In the present study, we investigated the effects of AICA riboside on mitochondrial oxidative; phosphorylation."

"AICA riboside was found to dose-dependently inhibit the oligomycin-sensitive JO(2) (oxygen consumption rate) of isolated rat hepatocytes. A decrease in P-i (inorganic phosphate), ATP, AMP and total adenine nuclectide contents was also observed with AICA riboside concentrations > 0.1 mM....

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Source: Gastroenterology Week (2007-09-17)

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