Kidneys

Reports outline kidneys research from Chiba University, Medical Department

Published in Gastroenterology Week, April 21st, 2008

"Tubular-interstitial injury plays a key role in the progression of chronic kidney disease. Although endoplasmic reticulum (ER) stress plays significant roles in the development of chronic diseases such as neurodegenerative disease, cardiomyopathy and diabetes mellitus, its pathophysiological role in chronic renal tubular cell injury remains unknown," investigators in Chiba, Japan report.

"BiP is an essential chaperone molecule that helps with proper protein folding in the ER. Recently, we have produced a knock-in mouse that expresses a mutant-BiP in which the retrieval sequence to the ER is deleted in order to elucidate physiological processes that are sensitive to ER...

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Source: Gastroenterology Week (2008-04-21)

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