Karolinska Institutet

Novel mechanisms controlling insulin release and fat deposition discovered

Published in Gastroenterology Week, May 26th, 2008

[PRESS RELEASE, 13 May 200] Scientists at the Swedish medical university Karolinska Institutet have in two recent studies shown that a receptor called ALK7 plays important roles in the regulation of body fat deposition as well as the release of insulin from beta-cells in the pancreas. These findings have implications for the development of treatments against diabetes and obesity.

"We have shown in animal studies that removing the ALK7 receptor improves insulin release by beta-cells in the pancreas, and at the same time decreases fat deposition in situations of high caloric intake", says Professor Carlos Ibanez, who lead the two studies that are now published as...

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Source: Gastroenterology Week (2008-05-26)

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