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University of California - Davis - Health System

UC Davis researchers discover Achilles' heel in pancreatic cancer

Published in Gastroenterology Week, November 24th, 2008

UC Davis Cancer Center researchers have discovered a metabolic deficiency in pancreatic cancer cells that can be used to slow the progress of the deadliest of all cancers.

Published in the October issue of the International Journal of Cancer, study results indicate that pancreatic cancer cells cannot produce the amino acid arginine, which plays an essential role in cell division, immune function and hormone regulation. By depleting arginine levels in cell cultures and animal models, the team was able to significantly reduce pancreatic cancer-cell proliferation.

"There have been few significant advances in 15 years of testing available chemotherapy to...

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