Dana-Farber Cancer Institute

Protein levels indicate risk of death in some colorectal cancer patients

Published in Gastroenterology Week, December 22nd, 2008

BOSTON--A pair of proteins may help explain why people with surgically removed colorectal cancer and who are overweight, physically inactive, and follow a Western-pattern diet may have an increased risk of dying of the disease or other causes, Dana-Farber Cancer Institute scientists report in a new study.

The researchers found that in people who have undergone surgery for colorectal cancer, the levels of two insulin-related proteins in their blood before diagnosis predicted their chances of dying from the cancer or other conditions. Patients with high prediagnosis levels of insulin-like growth factor binding protein-1 (IGFBP-1) were more than half as likely to succumb...

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Source: Gastroenterology Week (2008-12-22)

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