RNA Research

Data on RNA research discussed by P. Buongiorno and colleagues

Published in Gastroenterology Week, December 22nd, 2008

"beta-catenin is a key mediator of the canonical Wnt pathway as it associates with members of the T-cell factor (TCF) family at Wnt-responsive promoters to drive the transcription of Wnt target genes. Recently, we showed that Rac1 GTPase synergizes with beta-catenin to increase the activity of a TCF-responsive reporter," researchers in Toronto, Canada report.

"This synergy was dependent on the nuclear presence of Rac1, since inhibition of its nuclear localization effectively abolished the stimulatory effect of Rac1 on TCF-responsive reporter activity. We hypothesised that Rac1 plays a direct role in enhancing the transcription of endogenous Wnt target genes by...

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Source: Gastroenterology Week (2008-12-22)

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