Hepatitis C Virus

Reports from University of Birmingham describe recent advances in hepatitis C virus

Published in Gastroenterology Week, March 2nd, 2009

"Hepatitis C virus (HCV) primarily replicates within the liver, leading to hepatitis, fibrosis, and hepatocellular carcinoma. Infection is also associated with B-cell abnormalities, suggesting an association of the virus with B cells," researchers in Birmingham, the United Kingdom report.

"The infectious JFH-1 strain of HCV can bind primary and immortalized B cells but fails to establish productive infection. However, B cell associated virus readily infects hepatoma showing an enhanced infectivity compared with extracellular virus. B cells express the viral receptors CD81, SR-BI, and the C-type lectins DC-SIGN and L-SIGN. Antibodies specific for SR-BI and DC-SIGN/L-SIGN...

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Source: Gastroenterology Week (2009-03-02)

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