Gene Therapy
New gene therapy research reported from University of Nebraska
Published in Gastroenterology Week, May 25th, 2009
"Am J Physiol Renal Physiol 296: F847-F858, 2009. First published January 21, 2009; doi:10.1152/ajprenal.90438.2008.-The p53 tumor suppressor gene plays a crucial role in mediating apoptotic cell death in renal ischemia-reperfusion injury (IRI). To further elucidate the p53-dependent pathway, we investigated the role of the p53 apoptosis effector related to PMP-22 (PERP), an apoptosis-associated p53 transcriptional target. PERP mRNA and protein are highly induced in the...
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