Kidneys
Research findings from Tokyo Women's Medical University update understanding of kidneys
Published in Gastroenterology Week, May 25th, 2009
"To elucidate whether PTH(7-84), a degradation product of PTH(1-84), which inhibits PTH(1-84)-induced hone resorption, also exerts an antagonistic effect on the kidney, we studied the effect of PTH(7-84) on PTH(1-34)-induced production of 1,25-(OH)(2)D-3 in primary cultured murine renal tubules. Neonatal mouse renal tubules Cultured in serum-free MEM for 7 days were treated with PTH(1-34) and/or PTH(7-84)," investigators in Tokyo, Japan report.
"Three hours after addition of 25-OHD3 (10(6) M), 1,25-(OH)(2)D-3 was determined. PTH(1-34) stimulated the conversion of 25-OHD3 to 1,25-(OH)(2)D-3, and PTH(7-84) dose-dependently inhibited this process. Real-time PCR revealed...
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