Life Sciences
Research on life sciences reported by scientists at Seoul National University
Published in Gastroenterology Week, May 25th, 2009
According to a study from Seoul, South Korea, "microRNAs (miRNAs) play integral roles in diverse processes including tumorigenesis. miRNA gene loci are often found in close conjunction, and such clustered miRNA genes are transcribed from a common promoter to generate polycistronic primary transcript. The primary transcript (pri-miRNA) is then processed by two RNase III proteins to release the mature miRNAs."
"Although it has been speculated that the miRNAs in the same cluster may play related biological functions, this has not been experimentally addressed. Here we report that the miRNAs in two clusters (miR-106b93 25 and miR-222 221) suppress the Cip/Kip family members...
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