Gastroenterology Week
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Angiotensins
Reports from University of Pisa highlight recent research in angiotensins
July 13th, 2009
"Polymorphisms within the gene for transforming growth factor (TGF)-beta-1, a pro-fibrogenic cytokine pathophysiologically involved in hypertension and hypertensive target damage, might modulate the biological activity of the encoded protein. Through that mechanism, they might contribute to microalbuminuria, a marker of subclinical renal damage and a correlate of systemic inflammation and endothelial dysfunction in hypertension, a possibility never before tested," investigators in Pisa, Italy report. "For this reason, we assessed the association of four TGF-beta-1 polymorphic variants (C-509T, Leu(10)- > Pro, Arg(25)- > Pro, Thr(263)- > Ile) with albuminuria in...
Source: Gastroenterology Week (2009-07-13)
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