Hepatocellular Cancer

Study data from Temple University update knowledge of hepatocellular cancer

Published in Gastroenterology Week, July 13th, 2009

"Hepatitis C virus (HCV) infection is often associated with chronic liver disease, which is a major risk factor for the development of hepatocellular carcinoma (HCC). To study the HCV host-cell relationship on the molecular level, HepG2 and Huh7 cells were stably transfected with an infectious cDNA clone of HCV or with empty vector," researchers in the United States report.

"Evidence for HCV replication was obtained in both culture systems. HCV also stimulated growth in vitro. To identify genes whose altered expression by HCV are important to the pathogenesis of infection, RNAs were isolated from HepG2-HCV and HepG2-vector cells and subjected to microarray analysis. The...

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Source: Gastroenterology Week (2009-07-13)

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