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Physiology
Reports from Z. Shen et al highlight recent research in physiology
August 3rd, 2009
"Shen Z, Ajmo JM, Rogers CQ, Liang X, Le L, Murr MM, Peng Y, You M. Role of SIRT1 in regulation of LPS- or two ethanol metabolites-induced TNF-alpha production in cultured macrophage cell lines. Am J Physiol Gastrointest Liver Physiol 296: G1047-G1053, 2009," scientists in the United States report. "First published March 19, 2009; doi:10.1152/ajpgi.00016.2009.-Dysregulation of proinflammatory cytokines such as tumor necrosis factor-alpha (TNF-alpha) has been implicated in the pathogenesis of alcoholic liver injury. Sirtuin 1 (SIRT1) is an NAD(+)-dependent class III protein deacetylase that is known to be involved in regulating production of proinflammatory cytokines...
Source: Gastroenterology Week (2009-08-03)
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