BioMed Central

Chronic kidney disease linked to malfunctioning mitochondria

Published in Gastroenterology Week, September 7th, 2009

Chronic kidney disease (CKD) has been linked to oxidative stress caused by dysregulation of the genes that control mitochondria. A study in the open access journal BMC Genomics has revealed alterations in respiration gene expression in the white blood cells of CKD patients.

Gianluigi Zaza and Simona Granata, from the Renal Unit of University of Bari, Italy, led a team of researchers who carried out the genomic tests. Zaza said, "Our results suggest, for the first time, that CKD patients may have an impaired mitochondrial respiratory system and this condition may be both the consequence and the cause of enhanced oxidative stress".

The researchers...

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Source: Gastroenterology Week (2009-09-07)

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