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University of Chicago Medical Center
Protein critical for insulin secretion may be contributor to diabetes
November 9th, 2009
A cellular protein from a family involved in several human diseases is crucial for the proper production and release of insulin, new research has found, suggesting that the protein might play a role in diabetes. Mice lacking the ClC-3 channel, a passageway that allows negatively-charged chloride ions to pass through cell membranes, have only one-fifth the circulating insulin of normal mice, according to research published this month in the journal Cell Metabolism. Researchers Deborah Nelson and Louis Philipson of the University of Chicago, senior authors on the paper, argue that the finding may explain a portion of what goes wrong in Type 2 diabetes...
Source: Gastroenterology Week (2009-11-09)
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