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Colorectal Research

Reports from University of Oklahoma, Health Science Center add new data to research in colorectal research

Published in Gastroenterology Week, February 22nd, 2010

A new study, 'Importance of neural mechanisms in colonic mucosal and muscular dysfunction in adult rats following neonatal colonic irritation,' is now available. According to a study from the United States, "Previous studies have shown that early life trauma induced by maternal separation or colonic irritation leads to hypersensitivity to colorectal distension in adulthood. We tested the hypothesis that repetitive colorectal distension in neonates leads to abnormalities in colonic permeability and smooth muscle function in the adult rat."

"In neonatal rats, repetitive colorectal distension was performed on days 8, 10, and 12. As adults, stool consistency was graded from...

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