Cystic Fibrosis Genetics
Zunyi Medical College, Department of Gastroenterology details research in cystic fibrosis genetics
Published in Gastroenterology Week, March 1st, 2010
A new study, 'Differential activation of the HCO(3)(-) conductance through the cystic fibrosis transmembrane conductance regulator anion channel by genistein and forskolin in murine duodenum,' is now available. "Many cystic fibrosis (CF)-associated mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) anion channels affect CFTR-activated HCO(3)(-) transport more than Cl(-) transport. Targeting the CFTR HCO(3)(-) conductance, if possible, may therefore be of major therapeutic benefit," scientists writing in the British Journal of Pharmacology report.
"In the present study, we examined the effects of genistein and forskolin on duodenal mucosal...
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