Xenobiotics
Research from National Institute of Environmental Health Sciences in xenobiotics provides new insights
Published in Gastroenterology Week, March 8th, 2010
New research, 'Nuclear xenobiotic receptor PXR-null mouse exhibits hypophosphatemia and represses the Na/Pi-cotransporter SLC34A2,' is the subject of a report. According to recent research from the United States, "We previously found that the lack of nuclear xenobiotic receptor, PXR, decreases femoral bone mineral density (BMD) in Pxr-/-mice. Our present study aims to elucidate the inherited phenotype that correlates with the decreased BMD and to identify the PXR-regulated gene that may link with this phenotype."
"Pxr+/+ and Pxr-/-mice were used to measure the serum levels of inorganic phosphate (Pi), calcium and vitamin D3. Real time PCR and western blots were used to...
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