Gastroenterology

Research findings from N.J. Fudge et al update understanding of gastroenterology

Published in Gastroenterology Week, April 12th, 2010

According to a study from Canada, "Without the vitamin D receptor (VDR), adult mammals develop reduced intestinal calcium absorption, rickets, and osteomalacia. Intestinal calcium absorption normally increases during pregnancy so that the mother can supply sufficient calcium to her fetuses."

"The maternal skeleton is rapidly resorbed duringlactation to provide calcium needed for milk; that lost bone mineral content(BMC) is completely restored after weaning. We studied Vdr null mice to determine whether these adaptations during pregnancy and lactation require the VDR. Vdr nulls were severely rachitic at 10wk of age on a normal diet. Pregnancy induced a 158% increase in...

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Source: Gastroenterology Week (2010-04-12)

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