Cholangio Cancer Immunology
Report summarizes cholangio cancer immunology study findings from University of Pittsburgh, Thomas E. Starzl Transplantation Institute
Published in Gastroenterology Week, April 19th, 2010
New research, 'Estrogen stimulates female biliary epithelial cell interleukin-6 expression in mice and humans,' is the subject of a report. "Females are more susceptible than males to several biliary tract diseases. Interleukin-6 (IL-6) is critical to triggering autoimmune reactions and contributes substantially to biliary epithelial cell (BEC) barrier function and wound repair, and estrogen differentially regulates IL-6 expression in various cell types," scientists in the United States report.
"We hypothesized that estrogen might stimulate BEC IL-6 production. Exposure to physiologic levels of estradiol, in vitro, increased female mouse BEC (mBEC) IL-6 messenger RNA...
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