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Colitis

New Colitis Study Findings Have Been Published by Scientists at University of Erlangen

Published in Gastroenterology Week, August 15th, 2011

2011 AUG 15 -- According to the authors of recent research from Erlangen, Germany, "The transcription factor IRF4 is involved in several T-cell-dependent chronic inflammatory diseases. To elucidate the mechanisms for pathological cytokine production in colitis, we addressed the role of the IRF transcription factors in human inflammatory bowel disease (IBD) and experimental colitis."

"IRF levels and cytokine production in IBD patients were studied as well as the effects of IRF4 deficiency in experimental colitis. In contrast to IRF1, IRF5, and IRF8, IRF4 expression in IBD was augmented in the presence of active inflammation. Furthermore, IRF4 levels...

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