Gastroenterology

Reports from Catholic University Advance Knowledge in Gastroenterology

Published in Gastroenterology Week, February 6th, 2012

2012 FEB 6 -- "Hepatocyte differentiation is controlled by liver-enriched transcription factors (LETFs). We investigated whether LETFs control microRNA expression during development and whether this control is required for hepatocyte differentiation," scientists writing in the journal Gastroenterology report.

"Using in vivo DNA binding assays, we identified miR-122 as a direct target of the LETF hepatocyte nuclear factor (HNF) 6. The role and mechanisms of the HNF6-miR-122 gene cascade in hepatocyte differentiation were studied in vivo and in vitro by gain-of-function and loss-of-function experiments, using developing mice and zebrafish as model...

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Source: Gastroenterology Week (2012-02-06)

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