Cholangio Cancer
Research on Cholangio Cancer Published by Investigators at Tufts University
Published in Gastroenterology Week, February 6th, 2012
2012 FEB 6 -- "Human cholangiocytes are continuously exposed to millimolar levels of hydrophobic bile salt monomers. We recently hypothesized that an apical biliary HCO'3- umbrella might prevent the protonation of biliary glycine-conjugated bile salts and uncontrolled cell entry of the corresponding bile acids, and that defects in this biliary HCO'3- umbrella might predispose to chronic cholangiopathies," scientists in Boston, Massachusetts report.
"Here, we tested in vitro whether human cholangiocyte integrity in the presence of millimolar bile salt monomers is dependent on (1) pH, (2) adequate expression of the key HCO'3- exporter, anion exchanger 2...
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