Published in Gene Therapy Weekly, February 13th, 1995
For the purpose of immunization, the use of pure plasmid DNA has potential advantages over viral vectors. Advantages include ease and speed of production, easier quality control, non-integration of the DNA and lack of immunogenicity of the vector. Additional advantages such as ease and lower costs of production and heat stability of DNA would allow DNA to be shipped and stored in a lyophilized form - advantages that are especially important for use in developing nations.
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