Published in Gene Therapy Weekly, February 20th, 1995
Research suggests that early detection of cells carrying the t(14;18) (q32;q21) juxtaposition of the bcl-2 gene could be used to identify individuals at a high risk of developing non-Hodgkin's lymphoma (NHL). This is the most common translocation observed in NHL and occurs in 85 percent of follicular lymphomas. Upregulation of the bcl-2 gene is though to facilitate the accumulation of additional transforming mutations in...
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