Diagnostics

Increased Frequency of bcl-2 Oncogene Translocation in Heavy Smokers

Published in Gene Therapy Weekly, February 20th, 1995

A polymerase chain reaction-based assay (PCR) can be used to measure the frequency of mutations at the bcl-2 locus (a chromosomal translocation that is a hallmark of specific leukemias and lymphomas) in the peripheral blood of smokers and nonsmokers.

Research suggests that early detection of cells carrying the t(14;18) (q32;q21) juxtaposition of the bcl-2 gene could be used to identify individuals at a high risk of developing non-Hodgkin's lymphoma (NHL). This is the most common translocation observed in NHL and occurs in 85 percent of follicular lymphomas. Upregulation of the bcl-2 gene is though to facilitate the accumulation of additional transforming mutations in...

Want to see the full article?

Purchase this article for only $3.00

We're a pay-per-view site for premium content. If you'd like to purchase this article, it's only $3.00.

Welcome to NewsRx!

Learn more about a six-week, no-risk free trial of Gene Therapy Weekly

Source: Gene Therapy Weekly (1995-02-20)

NewsRx is Social

Top Medical Newsletters

Awards

Best Health/Healthcare Content, 2012
Best Health/Healthcare Content, 2011
Best e-Business Site, 2010
Best e-Business Site, 2009
Best e-Business Site, 2008
Best e-Business Site, 2007
Best e-Business Site, 2006
Best Healthcare Content, 2005
Best Overall Internet Site, 2005
Best Interactive Site, 2005

Facts & Stats

NewsRx also is available at LexisNexis, Gale, ProQuest, Factiva, Dialog, Thomson Reuters, NewsEdge, and Dow Jones.

Google 2010 PageRank: #2 Among Top Health News and Media Publications
Google 2010 PageRank: #2 Among Top Science Publications in Biology/Physiology
Google 2010 PageRank: #2 Among Top News and Media for the Business of Pharmaceuticals
Amazon's Alexa 2010 PageRank: #2 News and Media Site for the Pharmaceutical Industry