"Secretion of Lutropin and Follitropin from Transfected GH(3) Cells: Evidence for Separate Secretory Pathways."

According to the authors' abstract of an article published in Molecular Endocrinology, "Although lutropin (LH) and follitropin (FSH) are synthesized in the same pituitary gonadotropes, their secretion patterns in response to several experimental paradigms are not the same. Previous studies showing differences in secretion kinetics and the magnitude of hormone release by secretagogues imply differences in mechanisms for the storage and release of these hormones. To examine the secretory fate of LH and FSH, the genes encoding the common alpha-subunit and the corresponding beta-subunits were transfected in rat somatotrope-derived GH(3) cells, which contain regulated and constitutive...

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