Monoclonal Antibodies
Anti-Id MAbs Identify Neutralizing Anti-gp120 in HIV+
Published in Gene Therapy Weekly, February 27th, 1995
In previous studies researcher Kandasamy Hariharan and colleagues demonstrated that different anti-gp120 antibodies bearing unique idiotypes (ID+ Abs) isolated by a panel of anti-Id MAbs exhibit unique epitope specificity and neutralizing activity.
"This approach enabled us to analyze different neutralizing epitopes on gp120 and the cross-reactive anti-gp120 antibodies in two HIV-1 infected individuals," they wrote ("Analysis of B Cell Repertoire Specific to the Neutralizing...
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Source: Gene Therapy Weekly (1995-02-27)
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