Animal Models/Murine

Model for Polycystic Ovaries and Granulosa Cell Tumors Developed

Published in Gene Therapy Weekly, March 13th, 1995

A research team has developed a strain of mice that produces excessively high levels of luteinizing hormone (LH), a key reproductive hormone.

Female mice in the strain are sterile and develop reproductive tract abnormalities similar to those of women who also produce too much of the hormone.

Using the mouse model, scientists may be able to shed light on two conditions affecting American women, polycystic ovarian syndrome and granulosa cell tumors.

The research team, which included scientists funded by the U.S. National Institute of Child Health and Human Development (NICHD) and the U.S. National Institute of Diabetes and Digestive...

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Source: Gene Therapy Weekly (1995-03-13)

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