"Sustained Production of Human Transferrin by Transduced Fibroblasts Implanted into Athymic Mice: A Model for Somatic Gene Therapy."

According to the authors' abstract of an article published in Journal of Investigative Dermatology, "Somatic gene therapy has been proposed as a means of treating inherited diseases involving defective or absent plasma proteins, viral diseases, and cancer. Introduction of the gene of interest into fibroblasts and implantation of these genetically modified fibroblasts using a skin equivalent system may be an attractive model for gene therapy because skin fibroblasts are easily obtained and propagated in culture. This study evaluated expression of the gene for human transferrin (hTf) by genetically modified fibroblasts in vitro and in vivo. NIH 3T3 fibroblasts, which form...

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