Stem Cells

Function Not Indicated by Cell Surface Antigen Expression

Published in Gene Therapy Weekly, April 3rd, 1995

U.S. researchers stated that their study shows that in stem cell expansion experiments, cell surface antigen expression does not serve as an appropriate indicator of stem cell function.

Gerard L. Spangrude, National Institute of Allergy and Infectious Diseases, U.S. National Institutes of Health (NIH), Hamilton, Montana, and colleagues stated their observations show that caution should be exercised in experiments in which stem cell expansion is assessed by cell surface phenotype, because this property of stem cells may not always be associated with stem cell function ("Long-Term Repopulation of Irradiated Mice with Limiting Numbers of Purified Hematopoietic Stem Cells:...

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Source: Gene Therapy Weekly (1995-04-03)

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