"Upregulation of Integrins Alpha V Beta 3 and Alpha V Beta 5 on Human Monocytes and T Lymphocytes Facilitates Adenovirus-Mediated Gene Delivery."

According to the authors' abstract of an article published in Journal of Virology, "Entry of human adenovirus into host cells involves interaction of virus particles with two distinct receptors. The initial binding event is mediated by the fiber protein, while subsequent interaction of the penton base protein with alpha v integrins promotes virus internalization and/or penetration. Although these interactions in epithelial and endothelial cells have been well characterized, relatively little is known as to whether these events occur during virus infection of human peripheral blood mononuclear cells. We demonstrate that freshly isolated peripheral blood monocytes and T lymphocytes...

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