"Defective Retroviruses as Vaccine Vectors."

According to an abstract submitted by the authors to the New York Academy of Sciences conference DNA Vaccines: A New Era in Vaccinology, held April 6-9, 1995, "Cellular immunity, particularly the cytotoxic T lymphocyte (CTL) response, plays an important role in controlling the severity and duration of viral infections. Retroviral vector vaccines provide an efficient means of introducing and expressing genes encoding immunogens in mammalian cells. Hence, the vector can deliver foreign proteins to the appropriate antigen processing and presentation pathways for CTL activation. A non-replicating, amphotropic murine retroviral vector encoding the HIV-1 IIIB Env/Rev proteins has been...

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