Drug Development
"Production of a Recombinant Anti-Rhesus MAb with Insect Cells: Interest in Public Health."
Published in Gene Therapy Weekly, May 29th, 1995
According to an abstract submitted by the author to the 4th International Conference on Human Antibodies and Hybridomas, held April 26-28, 1995, in Amsterdam, The Netherlands, "At postpartum fetal red blood cells (RBC) enter the maternal circulation and induce immunization to the D-antigen in Rhesus (Rh) negative women. After further pregnancies the Rh antibodies provoke a hemolytic anemia in the fetus which needs in utero or ex sanguino transfusions in severe cases. The prevention of newborn hemolytic disease is obtained by injecting 100 pg of anti-Rh immunoglobulins in Rh negative women within 2 days postpartum or postabortion. Currently the Rh antibodies are polyclonal...
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Source: Gene Therapy Weekly (1995-05-29)
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