"Hepatocyte-Specific Binding of L/S-HBV Particles Expressed in Insect Cells."

According to the authors' abstract of an article published in Biological Chemistry Hoppe - Seyler, "The genome of hepatitis B virus (HBV) codes for three surface antigen proteins. Two of them are essential components of infectious viral particles. Whereas expression of the small (S) antigen led to formation of virus-like particles in different systems so far, secretion of neither the large antigen nor budding of virus-like particles containing both antigens could be observed. Using modified large antigen genes in dual expression vectors we were able to demonstrate secretion of virus-like particles in the baculovirus insect cell system. N-terminal fusion of an insect protein (melittin)...

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