Vectors
New Strategy Improves Adenovirus Vector for Gene Therapy
Published in Gene Therapy Weekly, June 12th, 1995
Adenoviruses are particularly attractive expression vectors for human gene therapy because they are relatively stable, can infect non-replicating cells, and have already been proven safe in humans. But currently available adenoviruses can carry only a small amount - about 8 kb - of foreign DNA. Moreover, infected cells "leak" adenovirus proteins that might be immunogenic or even toxic.
Baylor University researchers Kohnosuke Mitani, Stefan Kochanek, and colleagues now report that they have developed a strategy for increasing the carrier capacity of...
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Source: Gene Therapy Weekly (1995-06-12)
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