Published in Gene Therapy Weekly, June 12th, 1995
Adenoviruses are particularly attractive expression vectors for human gene therapy because they are relatively stable, can infect non-replicating cells, and have already been proven safe in humans. But currently available adenoviruses can carry only a small amount - about 8 kb - of foreign DNA. Moreover, infected cells "leak" adenovirus proteins that might be immunogenic or even toxic.
Baylor University researchers Kohnosuke Mitani, Stefan Kochanek, and colleagues now report that they have developed a strategy for increasing the carrier capacity of...
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