"A Novel Positional Humanization Method Generates Human Consensus Frameworks: Humanized BrE-3 and Mc3 for Breast Cancer Therapy."

According to an abstract submitted by the authors to the 4th International Conference on Human Antibodies and Hybridomas, held April 26-28, 1995, in Amsterdam, The Netherlands, "We used a positional consensus method in the previous humanization of the two murine antibodies BrE-3 and KC4G3. The method dictates that residues in certain conserved positions must be retained in order to guarantee the preservation of the original binding properties. Indeed these previous humanizations were completely successful. These frameworks were 90-97% identical to 'ideal' human consensus frameworks. Nevertheless, we speculated that the positional consensus may be unnecessarily too conservative with...

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