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Hypertensive Diseases

A Tissue Kallikrein Gene Shows Possibility for Treating Hypertension

Published in Gene Therapy Weekly, June 19th, 1995

The application of kallikrein gene therapy may be appropriate for the treatment of human hypertensive diseases.

In addition, the muscle delivery system may serve as a suitable model for human gene therapy for hypertensive diseases, indicated William Xiong and colleagues, Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina.

Xiong et al. demonstrated that direct delivery of the tissue kallikrein gene by a single muscle injection can cause a sustained reduction in blood pressure ("Muscle Delivery of Human Kallikrein Gene Reduces Blood Pressure in Hypertensive Rats," Hypertension, April...

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