Chemotherapy

Possible Reduction of Side Effects with Gene Therapy

Published in Gene Therapy Weekly, June 19th, 1995

Researchers at Case Western Reserve University (CWRU), Cleveland, Ohio, have developed a new gene therapy application in mice to protect healthy tissues that one day may be available for humans undergoing chemotherapy.

In a study published in the June 1, 1995, issue of the journal Blood, the researchers write that a novel drug-resistance gene called MGMT can be successfully transferred into bone marrow cells, the most susceptible of the body's tissues to chemotherapy damage.

These genetically altered marrow stem cells remain active a year after transplantation back into the animals. The MGMT gene encodes the cells to produce an enzyme called...

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Source: Gene Therapy Weekly (1995-06-19)

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