Oncogenesis

Use of Viral Vectors Could Stimulate Tumor Transformation

Published in Gene Therapy Weekly, July 3rd, 1995

Recent study suggests that insertion of foreign DNA can extensively alter the patterns of cellular DNA methylation and contribute to tumorigenic transformation.

Previous work has suggested that insertional mutagenesis disrupts cellular DNA at the immediate locus of foreign DNA integration. Recently, this concept has been extended to include affectation at many different cellular sites close to and/or remote from the original locus of foreign DNA insertion.

Hilde Heller et al. investigated the possibility that DNA from viral vectors could induce oncogenic changes in Ad12-induced tumors in hamsters ("Chromosomal Insertion of Foreign (Adenovirus Type...

Want to see the full article?

Purchase this article for only $3.00

We're a pay-per-view site for premium content. If you'd like to purchase this article, it's only $3.00.

Welcome to NewsRx!

Learn more about a six-week, no-risk free trial of Gene Therapy Weekly

Source: Gene Therapy Weekly (1995-07-03)

NewsRx is Social

Top Medical Newsletters

Awards

Best Health/Healthcare Content, 2012
Best Health/Healthcare Content, 2011
Best e-Business Site, 2010
Best e-Business Site, 2009
Best e-Business Site, 2008
Best e-Business Site, 2007
Best e-Business Site, 2006
Best Healthcare Content, 2005
Best Overall Internet Site, 2005
Best Interactive Site, 2005

Facts & Stats

NewsRx also is available at LexisNexis, Gale, ProQuest, Factiva, Dialog, Thomson Reuters, NewsEdge, and Dow Jones.

Google 2010 PageRank: #2 Among Top Health News and Media Publications
Google 2010 PageRank: #2 Among Top Science Publications in Biology/Physiology
Google 2010 PageRank: #2 Among Top News and Media for the Business of Pharmaceuticals
Amazon's Alexa 2010 PageRank: #2 News and Media Site for the Pharmaceutical Industry