Published in Gene Therapy Weekly, July 3rd, 1995
Previous work has suggested that insertional mutagenesis disrupts cellular DNA at the immediate locus of foreign DNA integration. Recently, this concept has been extended to include affectation at many different cellular sites close to and/or remote from the original locus of foreign DNA insertion.
Hilde Heller et al. investigated the possibility that DNA from viral vectors could induce oncogenic changes in Ad12-induced tumors in hamsters ("Chromosomal Insertion of Foreign (Adenovirus Type...
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