Clinical Trials - Gene Therapy
"Combined Experience from Phase I Studies with Allovectin-7, a Direct Gene Transfer Immunotherapeutic, in Patients with Metastatic Solid Tumors."
Published in Gene Therapy Weekly, July 3rd, 1995
According to an abstract submitted by the authors to the 31st Annual Meeting of the American Society of Clinical Oncology, held May 20-23, 1995, in Los Angeles, California, "Gene therapy provides a novel approach to increase tumor cell recognition by the immune system through the introduction of immunogenic gene products. We report here the combined experience from Phase I trials involving intralesional injections of Allovectin-7 in patients with metastatic melanoma, renal cell or colorectal carcinoma. The gene transfer product is a highly purified DNA plasmid driving the expression of encoded sequences for the major histocompatibility complex MHC HLA B-7 heavy chain and...
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Source: Gene Therapy Weekly (1995-07-03)
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