"Only a Very Specific Antisense 20mer Oligodeoxyl-Nucleotide Inhibits HIV RNA Dimer Formation."

According to an abstract submitted by the authors to the 95th General Meeting of the American Society for Microbiology, held May 21-25, 1995, in Washington, D.C., "One of the unique features of HIV (also other retroviruses) is that viral RNA exists as duplex linked together by the dimer linkage structure located in a region close to their 5' end. The partial sequence of HIV-1 RNA containing the dimer linkage structure (#532-#1078 of HXB2) with extra 4 nucleotides derived from the vector was prepared with T7 polymerase. This RNA formed dimer in vitro in the presence of relatively high salt (300mM KCI, SmM MgC12). Using this system we tested (up to 10) antisense 20mer oligonucleotides...

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