Published in Gene Therapy Weekly, July 17th, 1995
Although EBV viral genes are expressed in latently infected B lymphocytes and function in cellular growth control, genetic analysis has been cumbersome up to this point for two reasons. One, the viral genome is too large to permit genetic engineering; and two, human primary B lymphocytes, the only targets for infection by EBV in vitro, are intractable in culture and recalcitrant to DNA transfection.
Bettina Kempkes et al. overcame these problems by assembling all the essential EBV genes on a single...
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